ARBIDOL

Arbidol®  instructions

 

translated from original Russian instructions.

 

Name in Cyrillic : АРБИДОЛ

 

Active substance : Umiphenovir

 

Pharmachologic effect : Arbidol is an antiviral

 

Pharmacodynamics:

 

Arbidol suppresses influenza A and B viruses, coronavirus associated with severe acute respiratory syndrome (SARS). By the mechanism of antiviral action Arbidol refers to the inhibitors of fusion (fusion), Arbidol interacts with the hemagglu-tinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. Arbidol has moderate immunomodulatory effect. It has interferon-inducing activity, stimulates humoral and cellular immunity reactions, pha-gocytic function of macrophages, increases the body's resistance to viral infections. Arbidol reduces the incidence of complications associated with a viral infection, as well as exacerbations of chronic bacterial diseases.

 

Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phe-nomena, and in reducing the duration of the disease.

Arbidol refers to low-toxic drugs., it does not have any negative effects on the human body when administered orally at recommended doses.

 

Pharmacokinetics:

 

Arbidol is quickly absorbed and distributed to organs and tissues. The maximum concentration in blood plasma when ta-ken in a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg - after 1.5 hours. Metabolized in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in an insignificant number of kid-neys (0.12%). During the first day, 90% of the administered dose is discharged.

 

Indications :

 

Prevention and treatment in adults and children:

 

- influenza A and B, acute respiratory viral infection, severe acute respiratory syndrome (SARS) (including those complica-ted by bronchitis, pneumonia);

-  secondary immunodeficiency states;

 

-  complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection. Prevention of postoperative infectious complications and normalization of immune status. Complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years.

 

Contraindications

 

Hypersensitivity to the drug, age less than 3 years.

 

Side effects

 

Rarely: allergic reactions.

 

Interaction

 

In the appointment with other drugs, no negative effects were noted.

 

Dosing and Administration

 

Arbidol is taken before eating. Single dose for children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg,

over 12 years and adults - 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg).

 

For non-specific prophylaxis:

 

In direct contact with patients with influenza and other SARS:

 

Children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg once a day for 10-14 days.


During the epidemic of influenza and other acute respiratory infections, to prevent exacerbations of chronic bronchitis, recurrence of herpetic infection:

Children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg twice a week for 3 weeks.

 

For prevention of SARS (when in contact with a patient):

 

Adults and children over 12 years of age are prescribed 200 mg once a day. Children from 6 to 12 years of 100 mg once a day (before meals) for 12-14 days.

 

Prevention of postoperative complications:

 

Children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg for 2 days before the operation, then on the 2-nd and 5 -th days after the operation.

 

For treatment:

 

Flu, other SARS without complications:

 

Children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days.

 

Influenza, other acute respiratory infections with complications (bronchitis, pneumonia, etc.): Children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose once a week for 4 weeks.

 

Severe Acute Respiratory Syndrome (SARS):

 

Children over 12 years and adults - 200 mg 2 times a day for 8-10 days.

 

In the complex treatment of chronic bronchitis, herpetic infection:

 

Children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week within 4 weeks.

 

Complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years:

 

From 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years - 200 mg

 

4 times a day (every 6 hours) for 5 days.

 

Special instructions

 

Arbidol does not show central neurotropic activity and can be used in medical practice for preventive purposes in practi-cally healthy persons of various professions, including requiring increased attention and coordination of movements (dri-vers of transport, operators, etc.).

 

Manufacturer

 

otc Pharm, Russia

 

Storage

 

The temperature is not above 25 ° C.

 

Keep out of the reach of children.

 

Shelf-life of the drug is 2 years.