Phenibut - official instructions for use


Dosage form:


Composition per 1 tablet:

Active ingredient - Phenibut 250 mg;

Auxiliary substances - lactose, potato starch, calcium stearate.


Round flat-cylindrical with a facet and a risk of a tablet from white to white with a slightly yellowish hue of color.

Pharmacotherapeutic group:

Nootropic agent.

The ATX code is [N05BX].


Phenibut is a phenyl derivative of GABA and phenylethylamine. It has an anxiolytic effect, reducing tension, anxiety, fear and improving sleep; Prolongs and intensifies the effect of sleeping pills, narcotic and neuroleptic drugs.


Phenibut - nootropic agent, facilitates GABA-mediated transmission of nerve impulses to the central nervous system (direct effect on GABA -ergic receptors). It also has a tranquilizing, psycho-stimulating, antiaggregant and antioxidant effect.

Improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral circulation (increases the volume and linear speed of cerebral blood flow, reduces the resistance of cerebral vessels, improves microcirculation, and has antiaggregant effect). Promotes the reduction or disappearance of feelings of anxiety, tension, anxiety and fear, normalizes sleep, has an anticonvulsant effect.

Does not affect cholino- and adrenergic receptors. It prolongs the latent period and shortens the duration and severity of nystagmus. Reduces the manifestations of asthenia and vasovegetative symptoms (including headache, a feeling of heaviness in the head, sleep disorders, irritability, emotional lability), increases mental performance.

It improves psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions). At the course reception increases physical and mental efficiency, improves memory, normalizes sleep; Improves the condition of patients with motor and speech disorders.

In patients with asthenia, from the first days of therapy improves well-being, increases interest and initiative (motivation of activity) without sedation or arousal.

People of advanced age do not cause central nervous system depression, muscle-relaxing aftereffect is most often absent.

Improves microcirculation in the tissues of the eye, reduces the oppressive effect of ethanol on the central nervous system. The drug is low-toxic, does not cause allergic effects, as well as teratogenic, embryotoxic and carcinogenic effects.


Absorption of the drug is high, it penetrates well into all tissues of the body and through the blood-brain barrier (BBB). In the brain tissue penetrates about 0.1% of the administered dose of the drug, and in young and old people to a much greater extent. Evenly distributed in the liver and kidneys. Metabolized in the liver -80-95%, metabolites are not pharmacologically active. Not cumulated. After 3 hours begins to be secreted by the kidneys, while the concentration in the brain tissue does not decrease and it is found in the brain for another 6 hours. About 5% is excreted by the kidneys unchanged, partly with bile.

Indications for use.

Asthenic and anxiety-neurotic states, anxiety, anxiety, fear; In children with stuttering and tics; In old age - with insomnia; For the prevention of anxiety conditions that arise before surgical interventions and painful diagnostic studies. As part of complex therapy for alcoholism for the relief of psychopathological and somatovegetative disorders with withdrawal syndrome. In combination with detoxification drugs, the drug can be used to treat pre-dilerial conditions with alcoholism.

Ménière's disease, dizziness associated with dysfunction of the vestibular analyzer of various genesis; For the prevention of motion sickness with kinetosis.


Individual intolerance, pregnancy (1 trimester), breastfeeding, children under 2 years.

With caution in case of erosive and ulcerative lesions of the gastrointestinal tract, liver failure.

Dosing and Administration.

Inside after eating 2-3-week courses. Adults: 250-500 mg 3 times a day. If necessary, in the future, the daily dose is increased to 2500 mg. Children from 2 to 8 years - 50-100 mg; From 8 to 14 years - 250 mg 3 times a day. A single maximum dose in adults is 750 mg, in adults over 60 years -500 mg, in children under 8 years - 150 mg, from 8 to 14 years - 250 mg.

For relief of alcohol withdrawal symptoms in the first days of treatment in the afternoon for 250-500 mg 3 times a day and at night 750 mg, with a gradual decrease in the daily dose to the usual for adults.

To treat dizziness with dysfunction of the vestibular apparatus and Meniere's disease, 250 mg 3 times a day for 14 days are prescribed.

For the prevention of motion sickness take in a dose of 250-500 mg once for 1 hour before the expected start of the rolling or with the appearance of the first mild symptoms of seasickness. The anti-sweating effect of Phenibut tablets increases with an increase in the dose of the drug. At the onset of severe manifestations of seasickness (vomiting, etc.), the reception of Phenybut tablets inside is ineffective even at doses of 750-1000 mg.

Side effect.

Drowsiness, nausea. Increased irritability, agitation, anxiety, dizziness, headache (at the first intake), allergic reactions (skin rash, itching).


Strengthening symptoms of side effects: severe drowsiness, nausea, vomiting, fatty liver (taking more than 7 g), eosinophilia, lowering blood pressure, impaired renal function. First aid - washing the stomach, taking activated charcoal and performing symptomatic therapy.

Interaction with other drugs.

For the purposes of mutual potentiation, the drug Fenibut can be combined with other psychotropic drugs, reducing the dose of the drug Fenibut and the drugs combined with it. Extends and intensifies the effect of sleeping pills, narcotic, neuroleptic and anticonvulsant drugs, alcohol. There is evidence of an increase in the effect of antiparkinsonian agents under the influence of the drug Fenibut.

Special instructions.

With prolonged use, it is necessary to monitor liver function and peripheral blood. It is necessary to refrain from potentially dangerous activities requiring increased attention.

Form of issue. Tablets of 250 mg. 10 tablets per contour cell pack. Contoured cell packs of 1; 2; 3; 4; 5 together with the instructions for use are placed in a pack of cardboard.

Shelf life. 3 years.

Do not use after the expiry date printed on the package.

Storage conditions. List B.

In dry, protected from light and out of reach of children at a temperature of no higher than 25 ° C.

Terms of leave from pharmacies. On prescription.

Buy PHENIBUT  20 tablets or PHENIBUT 120 tablets.