Buy Seretide Inhaler 25mcg/125mcg 120 doses

      Active ingredient: Salmeterol / Fluticasone

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1 inhaler x 120 doses

Short description

Seretide (salmeterol + fluticasone) is an anti-inflammatory and bronchodilator for use in pulmonary practice. The pharmacological effect of the medicinal product is determined by the active ingredients included in its composition, which have different directions of action. Salmeterol relieves bronchospastic symptoms. Fluticasone normalizes lung function and prevents the transition of the disease to the acute phase. The drug has a convenient way of dosing, which makes it an excellent alternative for patients who are forced to use inhalation monopreparations of the group of agonists of beta-2-adrenergic receptors and inhaled glucocorticosteroids from different vials. Salmeterol is a selective agonist of beta-2 adrenoreceptors of prolonged (up to 12 hours) action. Its pharmacological properties favorably distinguish it among short-acting beta-2-adrenoreceptor agonists: it more effectively protects against narrowing of the lumen of the bronchi provoked by histamine and provides a longer bronchodilator effect. Studies of salmeterol showed that this substance is capable of significantly suppressing the release of mediators of allergic reactions by the lung cells (histamine, leukotrienes, etc.). The substance inhibits the initial and late phases of the immune response to the effects of allergenic substances that enter the body through the respiratory tract. The suppression of the late phase of the immune response after using a single dose of the drug lasts more than a day, while the bronchodilator effect ceases. A single use of salmeterol reduces bronchial hypersensitivity. This suggests the presence of another mechanism of action, in addition to bronchodilating activity, the clinical significance of which has not yet been definitively determined.

 

The anti-inflammatory effect of glucocorticosteroids is based on a different path. Fluticasone is a local glucocorticosteroid that, when administered through the respiratory tract in the doses indicated in the package leaflet, has a powerful anti-inflammatory and antiallergic effect in the respiratory organs, which minimizes the risk of asthma passing into the acute phase. It is important that this active ingredient Seretid does not provoke undesirable side effects that occur when using glucocorticosteroids for systemic (oral, injectable) use. With prolonged use of fluticasone (including in submaximal and maximum dosages), the work of the adrenal cortex is not suppressed and remains within the physiological limits of patients of all age groups. After the withdrawal of other inhaled glucocorticosteroids and the appointment of fluticasone in patients, the secretory activity of the adrenal cortex gradually returns to normal. Fluticasone does not impair the reserve function of the adrenal cortex, as evidenced by a moderate increase in cortisol with appropriate stimulation. Before starting treatment, the patient should be informed that the optimal effect can be achieved only with regular use of Seretide. The drug should continue to be taken even after the disappearance of the signs of existing pulmonary pathology. Termination of admission is possible only in consultation with the doctor. During treatment, regular medical monitoring should be conducted to evaluate the effectiveness of drug therapy. The question of the duration of receiving Seretid and the possibility of adjusting its dose is decided by the doctor individually. In pediatric practice, the drug is used when the patient reaches four years of age.

Many people want to buy Seretide for its excellent properties. Seretide contains two medicines: salmeterol and fluticasone propionate. Salmeterol is a long-acting bronchodilator. Bronchodilators help the airways in the lungs to stay open. This makes it easier for air to get in and out. The effects last for at least 12 hours. Fluticasone propionate is a corticosteroid which reduces swelling and irritation in the lungs.

ASTHMA SYMPTOMS


Seretide side effects

Since Seretid contains salmeterol and fluticasone propionate, its side effects are characteristic of each of these drugs. Their simultaneous use does not cause additional side effects.

Seretide may cause paradoxical bronchospasm.

As part of clinical studies using Seretid, there have sometimes been reports of bruising, as well as frequent cases of pneumonia (in patients with COPD).

As part of post-marketing surveillance, the following data on adverse events was obtained.

 

Seretide 

Sometimes hypersensitivity reactions have been reported, incl. manifested as skin reactions, angioedema (mainly edema of the face and oropharynx), respiratory disorders (shortness of breath and / or bronchospasm), and in very rare cases - anaphylactic reactions.

Anxiety, behavioral disorders (including hyperactivity and irritability, mainly in children), sleep disorders, and hyperglycemia were also very rarely observed.

 

Salmeterol

On the part of the cardiovascular system: palpitations, headache (usually transient, decrease with the continuation of therapy salmeterol); in predisposed patients, cardiac arrhythmias are possible (including atrial fibrillation, supraventricular tachycardia, extrasystole).

On the part of the digestive system: rarely - abdominal pain, nausea, vomiting; in some cases - a violation of taste, irritation of the mucous membranes of the oropharynx.

Allergic reactions: rash, angioedema, local edema.

Other: tremor, hypokalemia (as a rule, transient, decrease with the continuation of therapy salmeterol); rarely - arthralgia, nervousness; very rarely - hyperglycemia; in some cases, painful muscle spasms.

 

Fluticasone Propionate

On the part of the respiratory system: hoarseness, candidiasis of the oral cavity and pharynx.

Allergic reactions: skin manifestations, angioedema (mainly of the face and oropharynx), respiratory symptoms (shortness of breath and / or bronchospasm), anaphylactic reactions.

Systemic reactions: it is theoretically possible to develop systemic reactions, including Cushing's syndrome, cushingoid symptoms, adrenal suppression, growth retardation in children and adolescents, reduced bone mineral density, cataracts and glaucoma.

Anxiety, sleep disorders and behavioral disorders, including hyperactivity and irritability (mainly in children), hyperglycemia have been reported very rarely.

 

Contraindications

  •        children's age up to 4 years;
  •        hypersensitivity to the drug.

Seretide should be prescribed with caution in case of pulmonary tuberculosis, fungal, viral or bacterial infections of the respiratory system, thyroxomycosis, diabetes mellitus, diabetes mellitus, uncontrolled hypokalemia, idiopathic hypertrophic subaortic stenosis, uncontrolled arterial hypertension, arrhythmias, or untreated hypertrophic subaortic stenosis, uncontrolled arterial hypertension, arrhythmias, or untreated hypertrophic subaortic stenosis, uncontrolled arterial hypertension, arrhythmias, or untreated hypertrophic subaortic stenosis; , cataract, glaucoma, hypothyroidism, osteoporosis, pregnancy, in the period of lactation.

Seretide for sale: Even if a prescription is not required, it is assumed that you have a valid prescription or doctor's recommendation. Please do not self-cure. Get expert advice before ordering. 

The product is intended for Russian market and can be labeled in Russian (Packaging design may vary). With detailed English printed manual. 

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SERETIDE 25/125mcg INHALER 120 doses

  • Product Code: SD25/125
  • Availability: In Stock
  • $44.96