Buy Afobazol (Afobazole) 10mg 60
tablets
Active ingredient: Fabomotizole
Free Shipping
Without prescription
1 box x 60 tablets
Afobazol is the new generation drug, a synthetic anxiolytic, it effectively restores the anti-stress resources of the human body, so it does not cause addiction and addiction in patients. In comparison with many sedative and anticonvulsants, Afobazol does not adversely affect physical activity and does not suppress the activity of the nervous system. After its administration, there are no side effects such as weakness, drowsiness, memory loss, absent-mindedness. In addition, Afobazol successfully copes not only with the psychological manifestations of stress and anxiety, but also eliminates physical disorders associated with the development of mental disorders.
Short
description
Afobazole is a selective anxiolytic according to its mechanism of action:
the drug counteracts the development of membrane-dependent changes in
gamma-aminobutyric acid receptors (GABA is the main inhibitory
neurotransmitter). It does not have a sedative effect (unless, of course, do
not exceed the recommended dose ten times). The pharmacological effect of Afobazole
is a combination of an anti-anxiety and a light activating component.
Already on the 5-7th day of taking Afobazol, a decrease or complete elimination of anxiety, irritability, anxious forebodings, tearfulness, phobias, and inability to relax is noted. Against this background, the combined somatic symptoms begin to disappear: muscle, cardiovascular, sensory, respiratory and digestive manifestations of pathological anxiety. The peak action of afobazole occurs at the end of the 4th week and persists for another 1-2 weeks after discontinuation of the drug.
Many people want to buy Afobazol(e) for its excellent properties. Afobazole has anxiolytic effect and used in anxiety
conditions, including burdened with somatic symptoms. To suppress such
conditions, medicine may propose, for example, benzodiazepine tranquilizers or
antidepressants. The problem is that these groups of drugs, in addition to the
undeniable advantages, are endowed with a number of disadvantages.
A reasonable alternative to eliminate pathological anxiety may be Afobazole. Its use is not associated with adverse reactions characteristic of the benzodiazepine tranquilizers - lethargy, drowsiness, muscle relaxation, impaired coordination of movement, which can impair the quality of life. At the same time, Afobazol has several advantages: low toxicity, the ability to use in complex therapy without increasing the risk of adverse reactions, low risk of addiction and withdrawal. Thus, the drug in its anxiolytic properties practically corresponds to benzodiazepines and is suitable for long-term pharmacotherapy, as devoid of side effects characteristic of tranquilizers.
Pharmacology
Afobazole® is a selective non-benzodiazepine
anxiolytic. Acting on sigma-1 receptors in brain nerve cells, Afobazole®
stabilizes GABA / benzodiazepine receptors and restores their sensitivity to
endogenous inhibitory mediators. Afobazole® also increases the bioenergetic potential
of nerve cells and protects them from damage (it has a neuroprotective effect).
The action of the drug is implemented mainly in the form of a combination of anxiolytic (anti-anxiety) and mild stimulating (activating) effects. Afobazol® reduces or eliminates anxiety (preoccupation, bad feelings, apprehension, irritability), tension (timidity, tearfulness, anxiety, inability to relax, insomnia, fear), somatic manifestations of anxiety (muscle, sensory, cardiovascular, respiratory, gastrointestinal -intestinal symptoms), autonomic disorders (dry mouth, sweating, dizziness), cognitive impairment (difficulty concentrating, impaired memory). Especially shown is the use of the drug in individuals with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, a tendency to emotional-stress reactions. The effect of the drug develops on the 5-7th day of treatment. The maximum effect is achieved by the end of 4 weeks of treatment and persists after an average of 1-2 weeks after treatment. Afobazol® does not cause muscle weakness, drowsiness and does not have a negative effect on concentration and memory. With its use, drug dependence is not formed and the “withdrawal" syndrome does not develop.
Pharmacokinetics
Suction
After oral administration, Afobazole® is well and rapidly absorbed from the gastrointestinal tract. Cmax - 0.130 + 0.073 μg / ml; TCmax - 0.85 ± 0.13 h.
Metabolism
Afobazole® undergoes a “first pass effect”
through the liver, the main areas of metabolism are hydroxylation along the
aromatic ring of the benzimidazole ring and oxidation along the morpholine
fragment. Afobazole® is intensively distributed over well-vascularized organs;
it is characterized by a rapid transfer from the central pool (blood plasma) to
the peripheral (highly vascularized organs and tissues).
Excretion
The half-life of Afobazole® when taken orally is 0.82 + 0.54 hours. The short half-life is due to the intense biotransformation of the drug and the rapid distribution from the blood plasma to organs and tissues. The drug is excreted mainly in the form of metabolites and partially unchanged with urine and feces.
With prolonged use, it does not cumulate in the body.
Dosage
It is applied inside, after food.
The optimal single dose is 10 mg; daily allowance
- 30 mg, distributed in 3 doses throughout the day, The duration of the course
of the drug is 2-4 weeks. If necessary, on the recommendation of a doctor, the
daily dose of the drug can be increased to 60 mg, and the duration of treatment
up to 3 months.
Overdose
With a significant overdose and intoxication, the
development of a sedative effect and increased drowsiness without manifestations
of muscle relaxation is possible. As an emergency, caffeine 20% solution in
ampoules of 1.0 ml 2-3 times a day subcutaneously is used.
Side effects
Allergic reactions are possible. Rarely, a headache that usually resolves on its own and does not require withdrawal the drug
Indications
Afobazole® is used
in adults with anxiety conditions:
·
generalized
anxiety disorders;
·
neurasthenia;
·
adaptation
disorders.
In patients with
various somatic diseases:
·
bronchial asthma;
·
irritable bowel
syndrome;
·
systemic lupus
erythematosus;
·
cardiac ischemia;
·
hypertonic
disease;
·
arrhythmias;
·
dermatological,
oncological and other diseases.
In the treatment
of:
·
sleep disturbances
associated with anxiety;
·
neurocirculatory
dystonia;
·
premenstrual
syndrome;
·
alcohol withdrawal
syndrome;
·
to alleviate the
"withdrawal" syndrome when quitting smoking.
Contraindications
·
individual
intolerance to the drug.
·
galactose
intolerance, lactase deficiency or glucose-galactose malabsorption;
·
pregnancy,
lactation;
·
children, under 18
years old.
Afobazol for sale: Even if a
prescription is not required, it is assumed that you have a valid
prescription or doctor's recommendation. Please do not self-cure. Get expert
advice before purchasing Afobazole online. |
The drug images are for illustrative purposes only and
may differ from the actual product.
The product is intended for the Russian market and can
be labeled in Russian (Packaging design may vary). With
detailed English printed manual.
AFOBAZOL 10mg 60 tablets
- Product Code: AF10X60
- Availability: In Stock
-
$21.98
- Ex Tax: $21.98
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